Biochemical and histopathological investigation of the protective effect of disulfiram in ischemia-induced ovary damage

Isaoglu U., Yilmaz M., Calik M., Polat B., Bakan E., Kurt A., ...Daha Fazla

Gynecological Endocrinology, cilt.28, sa.2, ss.143-147, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3109/09513590.2011.589922
  • Dergi Adı: Gynecological Endocrinology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.143-147
  • Anahtar Kelimeler: Disulfiram, Ischemia, Ovary
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Hayır

Özet

It was biochemically and histopathologically investigated whether disulfiram has protective effects on ischemia-induced ovary damage. For this purpose, levels of tGSH, superoxide dismutase (SOD), malondialdehyde (MDA), and 8-OH Gua/Gua were investigated in ischemic rat ovary tissue. Results show that used doses of disulfiram (10, 25, and 50mg/kg) prevent MDA, a product of ischemia-induced lipid peroxidation, formation in female rat ovary tissue and prevent decrease of enzymatic and non-enzymatic (SOD, GSH) antioxidant parameters. Additionally, all doses of disulfiram significantly prevent DNA damage when compared to control group. Fewer histopathological findings were observed in tissues with higher antioxidant levels and lower oxidant and DNA damage levels. © 2012 Informa UK, Ltd.