Anti-inflammatory activity of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride

Suleyman H., GÜL H. İ., Asoglu M.

Pharmacological Research, cilt.47, sa.6, ss.471-475, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 6
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s1043-6618(03)00015-x
  • Dergi Adı: Pharmacological Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.471-475
  • Anahtar Kelimeler: Anti-inflammatory activity, Hyaluronidase activity, Indomethacin, Mannich base, Piperodinol, Rat
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Hayır

Özet

In our study, the effects of the compound 3-benzoyl-1-methyl-4-phenyl-4-piperidinol hydrochloride (C1) and also an anti-inflammatory drug, indomethacin, tested by carrageenan-induced paw edema and cotton pellet granuloma tests, for their effects on acute and chronic phases of inflammation, respectively. Their effects on vascular permeability were also tested by hyaluronidase-induced capillary permeability. C1 decreased the carrageenan-induced paw edema 61.98, 80.84, and 90.32% at 50, 100, and 200mgkg-1 doses, respectively, while this decrease was 89.93% by indomethacin at 20mgkg-1 dose. Antiproliferative effects of C1 at 100mgkg-1 and indomethacinin at 20mgkg-1 doses were 46.1 and 43.1%, respectively, in cotton pellet test. C1 and indomethacin both significantly inhibited the hyaluronidase-induced increase in capillary permeability. © 2003 Elsevier Science Ltd. All rights reserved.