LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago stellata)

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Kızıltaş H., Bingol Z., Gören A. C., Kose L. P., Durmaz L., Topal F., ...Daha Fazla

Molecules (Basel, Switzerland), cilt.26, sa.9, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 9
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3390/molecules26092469
  • Dergi Adı: Molecules (Basel, Switzerland)
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Metadex, Veterinary Science Database, Directory of Open Access Journals, Civil Engineering Abstracts
  • Anahtar Kelimeler: Ferulago stellata, k&#305, nkor, acetylcholinesterase, antioxidant activity, &#945, -glycosidase, &#945, -amylase, polyphenol content, LC-HRMS, IN-VITRO ANTIOXIDANT, RADICAL SCAVENGING ACTIVITY, ALPHA-GLUCOSIDASE INHIBITORS, LYOPHILIZED AQUEOUS EXTRACT, POLYPHENOL CONTENTS, ANTIRADICAL ACTIVITIES, CARBONIC-ANHYDRASE, PHENOLIC-COMPOUNDS, ANTIMICROBIAL ACTIVITIES, ANALGESIC ACTIVITIES
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

Kınkor (Ferulago stellata) is Turkish medicinal plant species and used in folk medicine against some diseases. As far as we know, the data are not available on the biological activities and chemical composition of this medicinal plant. In this study, the phytochemical composition; some metabolic enzyme inhibition; and antidiabetic, anticholinergic, and antioxidant activities of this plant were assessed. In order to evaluate the antioxidant activity of evaporated ethanolic extract (EEFS) and lyophilized water extract (WEFS) of kınkor (Ferulago stellata), some putative antioxidant methods such as DPPH· scavenging activity, ABTS•+ scavenging activity, ferric ions (Fe3+) reduction method, cupric ions (Cu2+) reducing capacity, and ferrous ions (Fe2+)-binding activities were separately performed. Furthermore, ascorbic acid, BHT, and α-tocopherol were used as the standard compounds. Additionally, the main phenolic compounds that are responsible for antioxidant abilities of ethanol and water extracts of kınkor (Ferulago stellata) were determined by liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Ethanol and water extracts of kınkor (Ferulago stellata) demonstrated effective antioxidant abilities when compared to standards. Moreover, ethanol extract of kınkor (Ferulago stellata) demonstrated IC50 values of 1.772 μg/mL against acetylcholinesterase (AChE), 33.56 ± 2.96 μg/mL against α-glycosidase, and 0.639 μg/mL against α-amylase enzyme respectively.