The Effect of Anakinra on Paclitaxel Induced Auditory Nerve Damage in Rats

BAYRAM R., ERHAN E., SEÇKİN E., SALCAN İ., MAMMADOV R., KURT N., ...Daha Fazla

ACTA FARMACEUTICA BONAERENSE, cilt.39, sa.2, ss.285-290, 2020 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 2
  • Basım Tarihi: 2020
  • Dergi Adı: ACTA FARMACEUTICA BONAERENSE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.285-290
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

SUMMARY. In this study, we have examined the protective and proinflammatory effects of anakinra

against paclitaxel-associated oxidative auditory nerve damage induced by paclitaxel in rats. Experimental

animals were allocated into three groups: Paclitaxel administered controls, paclitaxel + anakinra administered

group, and untreated health controls. At the end of this period, animals were sacrificed by

high dose thiopental (50 mg/kg) anesthesia and auditory nerves were removed. Then, malondialdehyde,

total glutathione, Interleukin-1β and nuclear factor kappa-B levels were measured in the auditory nerve

tissue. Our biochemical test results showed that paclitaxel significantly increased the amount of malondialdehyde

in auditory nerve tissue compared to anakinra and healthy group (P < 0.0001), whereas total

glutathione level decreased. In addition, paclitaxel was found to increase interleukin-1β and nuclear factor

kappa-B significantly compared to anakinra and healthy group (P < 0.0001). It was concluded that

anakinra is effective in suppressing paclitaxel related oxidative stress and proinflammatory events in auditory

nerve tissue.