Biochemically and histopathologically comparative review of thiamine's and thiamine pyrophosphate's oxidative stress effects generated with methotrexate in rat liver.

Demiryilmaz, Ismail; Şener, Ebru; Cetin, NİHAL; Altuner, DURDU; Suleyman, BAHADIR; ALBAYRAK, Fatih; Akcay, Fatih; Suleyman, HALİS

doi:10.12659/msm.883591

Biochemically and histopathologically comparative review of thiamine's and thiamine pyrophosphate's oxidative stress effects generated with methotrexate in rat liver.

Demiryilmaz I., Şener E., Cetin N., Altuner D., Suleyman B., ALBAYRAK F., ...Daha Fazla

Medical science monitor : international medical journal of experimental and clinical research, cilt.18, sa.12, 2012 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 18 Sayı: 12
Basım Tarihi: 2012
Doi Numarası: 10.12659/msm.883591
Dergi Adı: Medical science monitor : international medical journal of experimental and clinical research
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Erzincan Binali Yıldırım Üniversitesi Adresli: Hayır

Özet

Background: Oxidative liver injury occurring with methotrexate restricts its use in the desired dose. Therefore, whether or not thiamine and thiamine pyrophosphate, whose antioxidant activity is known, have protective effects on oxidative liver injury generated with methotrexate was comparatively researched in rats using biochemical and histopathological approaches.