Purpose This review aims to provide an up-to-date view on the toxicity profile, interactions and management of hypervitaminosis state of vitamin A, including its sources and metabolism. Methods While preparing this review, a comprehensive literature search was made by examining books, research/review articles, case control studies in detail, and the toxicity profile of vitamin A was shed light by bringing together the relevant information. Results Vitamin A is an important micronutrient mainly involved in the regulation of various cellular processes. Today, while vitamin A is used in the treatment of various diseases, it can also be supplied in the form of vitamin supplements without a prescription. Since it is a widely used vitamin, its toxicity is important. Acute toxicity may present with nonspecific findings such as headache, nausea, whereas chronic toxicity may present with specific findings such as gingivitis, intracranial hypertension. In addition, vitamin A has been shown to have teratogenic effects. Conclusion Considering the fact that vitamin A is available without a prescription, it can be argued that the risks of vitamin supplements should be well documented. Since vitamin A is a vitamin that causes harmful effects on the fetus, both deficiency and excess during pregnancy, more research is needed on both the dose and the duration of administration during this period. It is known that vitamin A interacts with various drugs and especially alcohol. Therefore, when using nutritional supplements containing vitamin A, the risk of interaction with concomitant medications and individual drinking habits should be considered.