Acute and chronic antiinflammatory profile of the ivy plant, Hedera helix, in rats

Süleyman H., Mshvildadze V., Gepdiremen A., Elias R.

Phytomedicine, cilt.10, sa.5, ss.370-374, 2003 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 5
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1078/0944-7113-00260
  • Dergi Adı: Phytomedicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.370-374
  • Anahtar Kelimeler: Antiinflammatory, Carrageenan, Cotton pellet, Hedera helix, Inflammation, Ivy plant, Rats
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Hayır

Özet

Hedera helix is a plant well-known as ivy or English ivy, and a member of the Araliaceae family. In the present study, we tested the possible antiinflammatory effects of a crude saponin extract (CSE) and a saponin's purified extracts (SPE) of Hedera helix in carrageenan- and cotton-pellet-induced acute and chronic inflammation models in rats. Both the CSE and SPE of Hedera helix were found to have antiinflammatory effects. The most potent drug screened was indomethacin (89.2 % acute antiinflammatory effect), while the most potent extract screened was the CSE of Hedera helix at 100 and 200 mg/kg body wt. doses with 77% acute antiinflammatory effects. For testing chronic antiinflammatory (antiproliferative) effects, the cotton-pellet-granuloma test was conducted. Indomethacin was found to be the most potent drug in the chronic phase of inflammation, with 66% effect. The SPE of Hedera helix was more potent than the CSE in its chronic antiinflammatory effect (60% and 49%, respectively).